Innovative, drip-free nasal application

Natesto is a no-drip, testosterone-containing gel. Each application takes about 10 seconds, applying a thin layer of gel that absorbs into the lining of the nose.

Close-up of a man's nose with a Natesto dispenser in the left nostril.
One pump (5.5 mg) in each nostril 3 times daily, for a total daily dose of 33 mg
Prescription pad that says 6 to 8 hours.
Each dose should be taken 6 to 8 hours apart: once in the morning, once in the afternoon, once in the evening
Alarm clock.
Try to use Natesto at the same times each day


84% of men were confident applying natesto

within 2 days*

*From a survey of 66 men who used Natesto for 90 days in a phase 3 study.

Learn how to use Natesto

Select each step to get familiar with applying Natesto.

A man's hand holding a Natesto dispenser upside down.


When starting a new dispenser, be sure to prime the pump before the first use:

  • Hold the dispenser upside down and push down 10 times over the sink, then dry the tip
  • Safely wash away any dispensed gel. If any gel gets on the hands, wash them with warm water and soap

No priming is needed for subsequent uses of that pump.

TIP: It's time for a new dispenser when the top of the piston inside reaches the arrow at the top of the inside label. Reveal the inside label by unwrapping the outer flap from around the container.

Discreet, TSA-Compliant, pocket-sized dispenser makes it

easy to dose on the go

TSA=Transportation Security Administration.

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Important Safety Information

Who should not use Natesto?

Do not use Natesto if you:

  • Are a man who has breast cancer
  • Have or might have prostate cancer
  • Are pregnant or may become pregnant or are breastfeeding. Natesto may harm your unborn or breastfeeding baby

Talk to your doctor before using Natesto if you have any of the above conditions.

What should I tell my doctor before using Natesto?

Before using Natesto, tell your doctor about all of your medical conditions, including if you:

  • Have or have had nose (nasal) or sinus problems or nasal or sinus surgery
  • Have had a broken nose (fracture) within the past 6 months
  • Have or have had a fracture of your nose that caused the inside of your nose to be crooked (deviated anterior nasal septum)
  • Have or have had problems with swelling of the lining of your nose (mucosal inflammatory disorder)
  • Have breast cancer
  • Have or might have prostate cancer
  • Have urinary problems due to an enlarged prostate
  • Have heart problems
  • Have liver or kidney problems
  • Have problems breathing while you sleep (sleep apnea)

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, or herbal supplements.

Using Natesto with certain other medicines can affect each other. Especially tell your doctor if you take:

  • Insulin
  • Medicines that decrease blood clotting
  • Corticosteroids

How should I use Natesto?

  • Use Natesto exactly as your doctor tells you to. Your doctor will tell you how much Natesto to use and when to use it
  • Natesto is for use in your nose (intranasally) only
  • Natesto can be used 30 minutes after using a type of nasal spray called sympathomimetic decongestants such as oxymetazoline. Natesto should not be used with other nasal sprays. It is not known if Natesto is safe and effective when used with other nasal sprays

What are the possible side effects of Natesto?

Natesto may cause serious side effects, including:

  • Nose (nasal) problems. Signs and symptoms of nasal problems may include runny nose, congestion, sneezing, nosebleed, nasal discomfort, nasal scabbing, or nasal dryness
  • If you already have enlargement of your prostate gland, your signs and symptoms can get worse while using Natesto. This can include: increased urination at night, trouble starting your urine stream, having to pass urine many times during the day, having an urge that you have to go to the bathroom right away, having a urine accident, and being unable to pass urine or weak urine flow
  • Possible increased risk of prostate cancer. Your doctor should check you for prostate cancer or any other prostate problems before you start and while you use Natesto
  • Changes in red blood cells
  • Blood clots in your legs or lungs. Signs and symptoms of a blood clot in your legs can include leg pain, swelling, or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain
  • Possible increased risk of heart attack or stroke
  • In large doses, Natesto may lower your sperm count
  • Possible increased risk of liver problems. Signs and symptoms of liver problems may include: nausea or vomiting, yellowing of your skin or whites of your eyes, dark urine, or pain on the right side of your stomach area (abdominal pain)
  • Swelling of your ankles, feet, or body, with or without heart failure. This may cause serious problems for people who have heart, kidney, or liver disease
  • Enlarged or painful breasts
  • Problems breathing while you sleep (sleep apnea)

Call your doctor right away if you have any of the serious side effects listed above.

The most common side effects of Natesto include:

  • Increased prostate-specific antigen (a test used to screen for prostate cancer)
  • Headache
  • Runny nose
  • Nosebleeds
  • Nose pain
  • Sore throat
  • Cough
  • Upper respiratory infection
  • Sinus infection
  • Nasal scabs

Other side effects include more erections than normal for you or erections that last for a long time.

These are not all the possible side effects of Natesto. Call your doctor for medical advice about side effects.

Store Natesto between 68°F to 77°F (20°C to 25°C).

Keep Natesto and all medicines out of the reach of children.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

For more information, visit, or call 1-833-698-3786.


What is Natesto Nasal Gel?

Natesto is a prescription medicine that contains testosterone and is used to treat adult males who have low or no testosterone due to certain medical conditions. Your doctor will test the testosterone level in your blood before you start and while you are using Natesto.

Natesto should not be used by men with breast cancer, or known or suspected prostate cancer.

It is not known if Natesto is safe or effective to treat men who have low testosterone due to aging.

Safety and effectiveness of Natesto have not been established in children younger than 18 years old, and Natesto should not be used by children. Natesto use by children may affect bone growth.

Natesto is a controlled substance (CIII) because it contains testosterone that can be a target for people who abuse prescription medicines. Keep your Natesto in a safe place to protect it. Never give your Natesto to anyone else, even if they have the same symptoms you have. Selling or giving away this medicine may harm others and is against the law.

Natesto is not meant for use in women.

Please see the Full Prescribing Information and Patient Information.

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